Piperacillin-Tazobactam

C. diff Risk

Medium

Oral Bioavailability

NA

Approximate Cost

Dosing

3.375 g IV every 8 hr (extended 4 hr infusion)

General Information

Common Usage

Broad spectrum agent with anti-pseudomonal activity.

Used for severe infections including:

  •  Pneumonia

  •  Intra-abdominal/hepatobiliary

  •  UTI

  •  Polymicrobial skin and soft tissue infection

  •  Febrile neutropenia

Drug Monitoring

Lab

  • Periodic CMP and CBC

Clinical

  • Hypersensitivity

  • Diarrhea

Adverse Effects

  • Allergy/rash (immediate or delayed)

  • Cytopenias- esp. thrombocytopenia

  • Eosinophilia

  • Interstitial nephritis

  • Abnormal liver enzymes

Major Interactions

Incr. levels of methotrexate

Pharmacology

Antimicrobial class: Ureidopenicillin with a beta-lactamase inhibitor

Pregnancy category: B

Average serum half life: 1 hour

Urine penetration: Therapeutic

CSF penetration: Poor

Biliary penetration: Therapeutic

Lung penetration: Therapeutic