Cephalexin

C. diff Risk

Medium

Oral Bioavailability

Moderate

Approximate Cost

Dosing

500 mg PO QID uncomplicated UTI - 500 mg PO BID

CrCl < 10 ml/min 500 mg PO BID

General Information

Common Usage

  •  Uncomplicated skin and soft tissue infection

  •  MSSA infections

  • UTI

Drug Monitoring

Clinical

  • Hypersensitivity

  • GI effects/Diarrhea

Adverse Effects

  •  Allergy/rash (immediate or delayed)

  •  Positive Coombs

  •  Cytopenias

  •  Eosinophilia

  •  Hepatic & renal laboratory abnormalities

Major Interactions

Increases metformin levels

Pharmacology

Antimicrobial class: First Generation Cephalosporin.

Pregnancy category: B

Urine penetration: Therapeutic

Lung penetration: Moderate

CSF penetration: Poor

Biliary penetration: Moderate