Micafungin

Restricted
Restricted

C. diff Risk

Low

Oral Bioavailability

NA

Approximate Cost

Spectrum Of Activity

Dosing

Requires Infectious Disease consultation for use OR completion of the Restricted Antimicrobial order form for approved indications

100 mg IV every 24 hr

General Information

Acceptable Uses

  • Invassive aspergillosis in patients refractory/intolerant to voriconazole and amphotericin B

  • Empiric treatment for ICU patients when candidemia is highly suspected

  • Candida infection not responsive to fluconazole

Unacceptable Uses

First line therapy for Candida or aspergillosis infections in non-critically ill patients

Common Usage

Therapy of suspected and confirmed invasive fungal infections

Drug Monitoring

Lab

  • periodic LFTs

Clinical

  • Hypersensitivity

  • GI effects

Adverse Effects

  • ¬†Increased liver enzymes

  • ¬†GI upset

Major Interactions

Increases levels of sirolimus and nifedipine (mild)

Pharmacology

Antimicrobial class: Echinocandin

Pregnancy category: C

Average serum half life: 15 hours

Biliary penetration: Therapeutic

CSF penetration: Poor

Lung penetration: Therapeutic

Urine penetration: Poor