Nitrofurantoin

C. diff Risk

Low

Oral Bioavailability

Excellent

Approximate Cost

Dosing

Cystitis Macrobid 100 mg PO BID

Contraindicated when CrCl < 60 ml/min

General Information

Common Usage

Uncomplicated cystitis in females with normal renal function

Adverse Effects

Interstitial pneumonitis and fibrosis especially with prolonged use.

Peripheral neuropathy.

Major Interactions

Antacids decrease absorption

Additional Information

Think of this drug as a urinary antiseptic.

Not recommended in males due to inadequate tissue penetration, especially with possible occult prostatitis.

Pharmacology

Antimicrobial class: Nitrofuran

Pregnancy category: B

Average serum half life: 1 hour

Biliary penetration: None

Lung penetration: None

Urine penetration: Therapeutic

CSF penetration: None