Oseltamivir

C. diff Risk

None

Oral Bioavailability

Excellent

Approximate Cost

Dosing

Immunocompromised or critically ill 75 mg PO BID x 5 days or longer in select patients Prophylaxis 75 mg PO daily

General Information

Common Usage

Treatment and prophylaxis of influenza

Adverse Effects

  • GI upset common

  • Rare - Stevens Johnson

  • Neuropsychiatric side effects reported

Major Interactions

No significant interactions

Additional Information

Higher doses (150mg PO BID) have not been shown to be superior but may be considered in critically ill or obese patients.

Pharmacology

Antimicrobial class: Antiviral - Neuraminidase inhibitor

Pregnancy category: C

Average serum half life: 2 hours

Lung penetration: Therapeutic