Requires Infectious Disease consultation for use OR completion of the Restricted Antimicrobial order form for approved indications 600 mg PO/IV every 12 hr Note: No restriction on oral therpy when being used to prepare patient for discharge
Documented VRE infection (not colonization)
Documented MRSA or methicillin-resistant coagulase-negative staphylococcal infection in a patient with a severe allergy to vancomycin
Documented vancomycin resistant Staphylococcus aures (VRSA) infection (MIC ≥ 2 mcg/ml)
Documented MRSA or methicillin-resistant coagulase-negative staphylococcal infection in a patient failing treatment with vancomycin despite adeqaute trough levels
Convenience (patients with renal dysfunction)
Empiric therapy for suspected staphylococcal infection
VRE colonization of the stool, urine, respiratory tract, wounds, or drains
Targeted or empiric therapy for gram positive infections including skin and soft tissue, and pneumonia.
Covers MRSA and VRE.
Visual changes/function with therapy ≥ 3 months
Elevated liver enzymes
Myelosuppression (usually with >2weeks therapy)- reversible
SSRI and other serotonergics/MAOIs - Increased risk of serotonin syndrome.
Rifampin decreases linezolid levels.
Antimicrobial class: Oxazolidinone
Pregnancy category: C
Average serum half life: 5 hours
Urine penetration: Therapeutic
Lung penetration: Therapeutic
CSF penetration: Therapeutic