Meropenem

C. diff Risk

Medium

Oral Bioavailability

NA

Approximate Cost

Dosing

Standard Dose
1 gm IV every 8 hr

Meningitis
2 gm IV every 8 hr

General Information

Common Usage

Therapy of serious, often nosocomial infections involving resistant gram negative organisms

Drug Monitoring

Lab

  • renal function

Clinical

  • Hypersensitivity

  • GI effects

  • siezures (rare)

Adverse Effects

  •  Immediate and delayed-type allergy

  •  GI disturbance

  •  Cytopenias, positive Coombs

  •  Liver enzyme abnormalities

Major Interactions

Valproic acid - Carbapenems decrease valproate levels and may decrease seizure threshold

Pharmacology

Antimicrobial class: Carbapenem

Pregnancy category: B

Average serum half life: 1 hour

Urine penetration: Therapeutic

Lung penetration: Therapeutic

CSF penetration: Moderate

Biliary penetration: Therapeutic