Therapy for herpesviral infections (HSV and VZV) including encephalitis.
Prophylaxis of herpesviral infections if recurrent disease or immunocompromised.
Follow SCr as appropriate
Check urine for crystals if AKI suspected
Ensure adequate hydration for the patient
Phlebitis (with IV formulation)
AKI from crystal nephropathy
CNS Effects (confusion, tremor, lethargy, hallucination)
Mycophenolate can increase the acyclovir concentration
May diminish efficacy of zoster or varicella vaccine
For oral indications, valacyclovir is the pro-drug, which is more bioavailable with more convenient dosing.
Antimicrobial class: Antiviral. Nucleoside analogue.
Pregnancy category: B
Average serum half life: 3 hours
Urine penetration: Therapeutic
CSF penetration: Therapeutic