Penicillin VK

C. diff Risk

Low

Oral Bioavailability

Moderate

Approximate Cost

Dosing

250-500 mg PO every 6-8 hr

No dose adjustment provided in manufacturer's labeling. Use with caution, excretion is prolonged in renal impairment.

General Information

Common Usage

Streptococcal infections and therapy of documented susceptible infection not requiring parenteral therapy (i.e. upper respiratory tract).

Prophylaxis after rheumatic fever.

Drug Monitoring

Lab

  • Periodic CBC, SCr

Clinical

  • ┬áMonitor for allergy

Adverse Effects

  • Allergy (anaphylaxis) and other rash

  • Cytopenias, Positive Coombs, Eosinophilia

  • Serum sickness

  • AIN

Major Interactions

No significant interactions

Pharmacology

Antimicrobial class: Penicillin

Pregnancy category: B

Average serum half life: 1 hour

Lung penetration: Therapeutic

Urine penetration: Therapeutic