Spectrum: Local Antimicrobial Stewardship, for Bakersfield Memorial Hospital

Ampicillin

C. diff Risk

Low

Oral Bioavailability

NA

Approximate Cost

Spectrum Of Activity

General Spectrum of Activity

General Spectrum of Activity

General Spectrum of Activity

Antibiogram Data

Dosing

Adult

1-2 g IV every 4-6 hr Meningitis or Endocarditis 2 g IV every 4 hr Oral 500 mg PO QID

Pediatric

Renal

General Information

Common Usage

Common Usage

Pathogen directed therapy for CNS, intravascular, intraabdominal, urinary and other infections especially Enterococcus and Listeria

Drug Monitoring

Drug Monitoring

Laboratory

  • Periodic renal and hematologic function

Clinical

  • rash or hypersensitivity reaction

Adverse Effects

Adverse Effects

Allergy and rash as for all beta-lactams

EBV related rash (not allergy)

Rare: cytopenias, +ve Coombs

Major Interactions

Major Interactions

Increased risk of rash with allopurinol

Pharmacology

Pharmacology

Antimicrobial class: Aminopenicillin

Pregnancy category: B

Average serum half life: 1 hour

Biliary penetration: Therapeutic

CSF penetration: Therapeutic

Lung penetration: Therapeutic

Urine penetration: Therapeutic