Ampicillin

C. diff Risk

Low

Oral Bioavailability

NA

Approximate Cost

Dosing

1-2 g IV every 4-6 hr

Meningitis or Endocarditis
2 g IV every 4 hr

Oral
500 mg PO QID

General Information

Common Usage

Pathogen directed therapy for CNS, intravascular, intraabdominal, urinary and other infections especially Enterococcus and Listeria

Drug Monitoring

Laboratory

  • Periodic renal and hematologic function

Clinical

  • rash or hypersensitivity reaction

Adverse Effects

Allergy and rash as for all beta-lactams

EBV related rash (not allergy)

Rare: cytopenias, +ve Coombs

Major Interactions

Increased risk of rash with allopurinol

Pharmacology

Antimicrobial class: Aminopenicillin

Pregnancy category: B

Average serum half life: 1 hour

Biliary penetration: Therapeutic

CSF penetration: Therapeutic

Lung penetration: Therapeutic

Urine penetration: Therapeutic