Cefazolin

C. diff Risk

Medium

Oral Bioavailability

NA

Approximate Cost

Dosing

1-2 g IV every 8 hr

General Information

Common Usage

Skin and soft tissue infection (e.g. cellulitis)

Surgical prophylaxis

Susceptible Staphylococcal, Streptococcal and gram negative infections

Drug Monitoring

Lab

  • CBC, CMP

Clinical

  • Hypersensitivity

  • GI effects

Adverse Effects

  • Allergy (immediate or delayed).

  • Can cause positive Coombs, cytopenias, and hepatic and renal laboratory abnormalities.

Major Interactions

Probenecid - prolonged half-life. Drug interaction has been used therapeutically to give once daily cefazolin.

Not recommended unless no other alternatives.

Pharmacology

Antimicrobial class: 1st Generation Cephalosporin

Pregnancy category: B

Average serum half life: 2 hours

Biliary penetration: Therapeutic

CSF penetration: Poor

Lung penetration: Therapeutic

Urine penetration: Therapeutic