Should not be used as monotherapy Tuberculosis 600 mg IV/PO every 24 hr Endocarditis 300 mg IV/PO every 8 hr Prosthetic joint/Osteomyelitis infections 450 mg IV/PO every 12 hr
Mycobacterial infections, Brucellosis, osteomyelitis, and prosthetic joint infections due to Staphyloccocus aureus (always use in combination with other agents).
abnormal liver enzymes
rash (Steven-Johnson syndrome)
Inducer of many CYP enzymes including 3A4, and 2C9. Review patients medications carefully.
Should never bee used as monotherapy
May discolor bodily secretions (yellow-reddish). Caution in contact lens wearers.
Antimicrobial class: Antimycobacterial
Pregnancy category: C
Average serum half life: 3-4 hr
Lung penetration: Therapeutic
Biliary penetration: Therapeutic
CSF penetration: Therapeutic
Route of Elimination: Feces