Ampicillin-Sulbactam

C. diff Risk

Medium

Oral Bioavailability

NA

Approximate Cost

Dosing

1.5-3 g IV every 6 hr

General Information

Common Usage

Skin and soft tissue infections

Polymicrobial infections of the respiratory tract or abdomen

Drug Monitoring

Lab

  • In patients with preexisting hepatic impairment, periodic hepatic funtion monitoring

Clinical

  • Hypersensitivity reactions

Adverse Effects

  • Allergy/Skin rash

  • Diarrhea

  • Pain at injection site/phlebitis

Major Interactions

Allopurinol - increased rash

Pharmacology

Antimicrobial class: Aminopenicillin

Pregnancy category: B

Average serum half life: 1 hour