Ceftolazone-Tazobactam

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C. diff Risk

High

Oral Bioavailability

NA

Approximate Cost

Spectrum Of Activity

Dosing

May only be ordered by an Infectious Disease Physician

1.5 g IV every 8 hr

General Information

Acceptable Uses

  • Reserved for multi-drug resistant (MDR) pseudomonas

  • Documented CRE infection

Unacceptable Uses

  • Emperic therpay

  • Management of non-multidrug resistant infections

Drug Monitoring

Lab

  • periodic CBC and CMP

Clinical

  • Hypersensitivity reaction

  • GI effects, diarrhea

Adverse Effects

  • GI intolerance

  • Hypersensitivity reaction

  • Headache

Pharmacology

Antimicrobial class: Cephalosporin combination

Pregnancy category: B

Average serum half life: Ceftolazone: 3 hr
Tazobactam: 1 hr

Route of Elimination: primarily urine