Cefoxitin

C. diff Risk

Medium

Oral Bioavailability

NA

Approximate Cost

Dosing

Adult

1-2 g IV every 6-8 hr

General Information

Common Usage

  • Perioperative pophylaxis in patients undergoing uncontaminated GI surgery, abdominal or vaginal hysterectomy, or cesarean section

Drug Monitoring

Lab

  • periodic SCr

Clinical

  • Hypersensitivity reaction

  • Diarrhea

  • INR (may enhace effects of warfarin)

Adverse Effects

  • GI effects, diarrhea

  • Hypersensitivity reaction

Major Interactions

  • May enhance nephrotoxic effects of aminoglycosides

  • enhances the anticoagulant effects of warfarin

Pharmacology

Antimicrobial class: Cephalosporin (second generation)

Average serum half life: 1.4 hr

CSF penetration: poor

Urine penetration: good

Biliary penetration: good

Lung penetration: good

Route of Elimination: primarily urine