Oxacillin

C. diff Risk

NA

Oral Bioavailability

NA

Approximate Cost

Dosing

1-2 g IV every 4-6 hr

No specific dose adjustment provided by the manufacturer

General Information

Common Usage

Treatment of MSSA infections

Drug Monitoring

Lab

  • Baseline and periodic CBC with differential

  • periodic urinalysis/CMP

Clinical

  • Hypersensitivity

  • Drug interactions (warfarin)

  • GI effects/diarrhea

Adverse Effects

  • Allergy

  • Phlebitis at injection site

  • C. difficile diarrhea

  • Abnormal liver enzymes

  • Cytonpenias

  • Interstitial nephritis

Major Interactions

  • Warfarin decreased PT/INR

Pharmacology

Antimicrobial class: Antistaphylococcal penicillin

Pregnancy category: B

Average serum half life: 0.9-1.8 hr

Urine penetration: Therapeutic

Lung penetration: Therapeutic

Biliary penetration: Moderate