Guidelines recommend that pre-operative antibiotics be initiated within 60 minutes of incision, except vancomycin and levofloxacin which need to be infused over 60-120 minutes.

Pre-operative antibiotic prophylaxis necessitates that the antimicrobial achieve acceptable serum and tissue concentrations at the time of incision as well as during the procedure in order to be effective.

Please see the following section for infusion time recommendations.