Penicillin Allergies

Note

Patients with Stevens-Johnson syndrome, toxic epidermal necrosis, DRESS or allergic interstitial nephritis as a result of penicillins, although unlikely to have a cross-reaction, should receive non-cephalosporin based regimens if possible based on the lack of data in this situation.

Considerations for Other Agents

Do not use aztreonam if patient is allergic to ceftazidime. Aztreonam shares the same side-chain as ceftazidime and thus cross-reactivity may occur.

Carbapenems are not expected to cross react if patient is allergic to penicillin or cephalosporins. Carbapenems are structurally dissimmilar to penicillins and cephalosporins and cross-reactivity is not expected when these agents are used.

References, Revisions and Approvals