Clostridium difficile Infection (CDI) - Treatment Notes

Treatment Notes

High Risk ABX:

  • Clindamycin

  • Ampicillin

  • Fluoroquinolones

  • 2nd and 3rd generation cephalosporins

  • carbapenems

  • Zosyn

Vancomycin given intravenously is NOT effective.

Cholestyramine or Rifampin are not recommended as adjunctive treatment or for prevention of recurrent CDAD as evidence regarding their efficacy is unclear.

Consider avoiding the following:

  • Proton pump inhibitors (PPIs),

  • Pro-motility agents and anti-peristaltic agents, including opiates and others such as loperamide.