Enterococcal Treatment / Infective Endocarditis

Native and Prosthetic Valve (PCN Susceptible Strains)

Plus

OR

*Recommended for patients with impaired renal function or who are at greater risk of developing nephrotoxicity from aminoglycoside use.

Native and Prosthetic Valve (PCN Resistant Strains)

PLUS

Duration

Patients with NVE and symptoms <3 months may be treated for 4 weeks; patients with PVE or NVE with symptoms ≥3 months should be treated for at least 6 weeks.

For adult patients with gentamicin-susceptible isolates, some experts shorten gentamicin component to two weeks when used in combination with a beta-lactam, particularly with emergence of nephrotoxicity.