CefTRIAXone

C. diff Risk

High

Oral Bioavailability

NA

Approximate Cost

Dosing

Adult

Usual Dose 1-2 g IV q24h

Bacterial meningitis 2 g IV q12h

Renal

No adjustment required

General Information

Common Usage

Empiric therapy of:

  • Bacterial meningitis

  • Endocarditis

  • Intra-abdominal Infections

  •  Nosocomial gram negative infections (except Pseudomonas)

  • Pneumonia

  •  Spontaneous bacterial peritonitis

  • Skin, bone/joint and soft tissue infections

  • Urinary Tract Infections

Adverse Effects

  •  Allergy/rash (immediate or delayed)

  •  Cytopenias

  •  Eosinophilia

  • GI disturbances (including diarrhea)

  •  Hepatic & renal laboratory abnormalities

  •  Pseudocholelithiasis (unclear clinical significance, commonly asymptomatic)

Pharmacology

Antimicrobial class: Parenteral Cephalosporin - 3rd Generation

Pregnancy category: B

Average serum half life: 8 hours

Biliary penetration: Therapeutic

CSF penetration: Therapeutic

Lung penetration: Therapeutic

Urine penetration: Therapeutic