C. diff Risk


Oral Bioavailability


Approximate Cost


No adjustment required

Usual indications
600 mg IV q8h (MSH Autosub dose)

Necrotizing SSTI or toxic shock syndrome
900mg IV q8h

Oral Dosing
300-450mg PO q6h

General Information

Common Usage

Anaerobic infections above the diaphragm, especially dental infection.

Gram positive skin and soft tissue infections including necrotizing fasciitis as an adjunctive agent to a beta lactam for reducing toxin production.

Skin & soft tissue infections involving susceptible MRSA.

Susceptible infections and surgical prophylaxis in setting of IgE mediated beta-lactam allergy.

For decreasing toxin production in toxic shock syndrome.

Drug Monitoring

None specific. Monitor for diarrhea.

Major Interactions

Muscle relaxants, e.g., atracurium, baclofen, diazepam.

St. Johns Wort


Antimicrobial class: Lincosamide

Pregnancy category: B

Average serum half life: 2.4 hours

Biliary penetration: Therapeutic

CSF penetration: Poor

Lung penetration: Therapeutic

Urine penetration: Poor