PO: 500-750mg po q12h
IV: 400mg IV q8-12h
Pseudomonal and other gram negative infections of urinary tract, bone/joint, abdomen and other sites.
Monitor QTc in patients with increased risk
Tendinopathy and rupture
CNS toxicity including confusion, psychosis
Weakness exacerbation in myasthenia gravis
CYP1A2 inhibitor - Multiple interactions possible.
QTc prolongation - Increased risk with other agents that prolong QTc.
Divalent & trivalent cations including Al, Ca, Fe, Mg (antacids, dairy products, iron supplements, some enteral feeds) - Decreased absorption
Cyclosporine - Increased levels of cyclosporine
Warfarin - Increased INR
Methadone - Lowered seizure threshold
Antimicrobial class: Fluoroquinolone
Pregnancy category: C
Average serum half life: 4 hours
Biliary penetration: Therapeutic
CSF penetration: Moderate
Lung penetration: Therapeutic
Urine penetration: Therapeutic