Cefepime

C. diff Risk

High

Oral Bioavailability

NA

Approximate Cost

Non-Formulary

Dosing

1-2g IV q8-12h

500mg-1g IV q24h
CrCl Less Than 11 mL/min

1-2g IV q24h
CrCl 11-29 mL/min

2g IV q12-24h
CrCl 30-50 mL/min

2 g IV q8-12h
CrCl Greater Than 60 mL/min

General Information

Unacceptable Uses

Cefepime is non-formulary at MSH.

Common Usage

Broad spectrum antimicrobial with gram positive and gram negative coverage including Pseudomonas.

Used especially nosocomial infections involving resistant organisms

Adverse Effects

  • Allergy (immediate & delayed)

  •  Positive Coombs

  •  Cytopenias

  •  Non-convulsive status epilepticus (resolves with discontinuation of cefepime)

  •  Elevated liver function tests

  •  Prolonged PT/PTT

  •  Infusion related reactions, including red man syndrome have been reported

  •  Headache

Pharmacology

Antimicrobial class: 4th generation Cephalosporin

Pregnancy category: B

Average serum half life: 2 hours

Biliary penetration: Moderate

Urine penetration: Therapeutic

CSF penetration: Therapeutic

Lung penetration: Therapeutic