Cloxacillin

C. diff Risk

Medium

Oral Bioavailability

NA

Approximate Cost

Dosing

Adult

1-2g IV q4-6h
Endocarditis: 2g IV q4h
250-500 mg IM q6h
250-500 mg PO QID

Renal

No adjustment required

General Information

Common Usage

Treatment of MSSA infections

Adverse Effects

  • Allergy (immediate or delayed)

  • Cytopenias

  • Eosinophilia

  • Interstitial nephritis

  • Abnormal liver enzymes

  • Phlebitis at injection site in a peripheral vein

Major Interactions

Can increase methotrexate levels.

Decrease mycophenolate levels.

Tetracyclines can diminish cloxacillin activity.

Pharmacology

Antimicrobial class: Antistaphylococcal Penicillin

Pregnancy category: B

Average serum half life: 1 hr

Biliary penetration: Moderate

Lung penetration: Therapeutic

Urine penetration: Therapeutic