C. diff Risk


Oral Bioavailability


Approximate Cost



Loading dose for Candidemia
800 mg IV/PO

Serious Infections
(e.g. Candidemia, CNS/Endophthalmitis/Endocarditis)
400-800 mg IV/PO daily

Other indications
100-400 mg IV/PO daily


CrCl Greater Than 50 mL/min
100-400 mg q24h

CrCl 10-49 mL/min
50% of dose q24h

CrCl Less Than 10 mL/min
25% of dose q24h

General Information

Common Usage

Candida infections both mucocutaneous and invasive - i.e. Candidemia.

Cryptococcus and Coccidioides infections.

Antifungal prophylaxis in immunocompromised.

Drug Monitoring

Consider QTc monitoring if concomitant drugs affecting the interval or elevated baseline measurement.

Adverse Effects

  • Drug interactions

  • QTc prolongation

  • Hepatic enzyme abnormalities

  • Rash

  • Alopecia

  • GI upset

Major Interactions

Many via CYP450. Suggest review specific patient medications.

Fluconazole increases levels of phenytoin, cyclosporine, tacrolimus, warfarin, oral hypoglycemics.

Risk when combining with other QTc prolonging medications.


Antimicrobial class: Triazole antifungal

Pregnancy category: C

Average serum half life: 20 hours

Urine penetration: Therapeutic

Lung penetration: Therapeutic

Biliary penetration: Therapeutic

CSF penetration: Therapeutic