Pseudomonal and other gram negative infections.
Inhaled form used in cystic fibrosis.
Monitor creatinine at least 3 times/week. Discontinue if any signs of ototoxicity.
Pharmacist will consult, adjust doses and order serum drug levels and renal function monitoring as per MSH Policy.
For indication specific peak and trough target levels, please refer to MSH Aminoglycoside Policy and consult pharmacy.
Avoid concomitant nephrotoxins
Less common with once daily dosing
Greater toxicity with longer duration and supratherapeutic trough levels
Require audiology testing if prolonged use
Can exacerbate neuromuscular blockade
Neuromuscular blockade agents - Respiratory paralysis.
Formal audiology assessment if planning to use aminoglycoside for >7d or if symptoms develop.
Inform patient of risk of ototoxicity and to report any symptoms
Antimicrobial class: Aminoglycoside
Pregnancy category: D
Average serum half life: 3 hours
Urine penetration: Therapeutic
Lung penetration: Therapeutic
CSF penetration: Poor
Biliary penetration: Moderate