Caspofungin

C. diff Risk

Low

Oral Bioavailability

NA

Approximate Cost

Dosing

Adult

70 mg IV once then 50 mg IV daily

Hepatic

Mild Impairment (Child-Pugh Class A):
No adjustment required

Moderate Impairment (Child-Pugh Class B):
70 mg IV once then 35 mg IV daily

Severe Impairment (Child-Pugh Class C):
The manufacturer provides to dosing guideline. Not studied.

General Information

Common Usage

Therapy of suspected and confirmed invasive fungal infections

Adverse Effects

  • ¬†Increased liver enzymes

  • ¬†GI upset

Major Interactions

Decreases levels of Tacrolimus
Cyclosporine may increase levels of Caspofungin
Rifampin may decrease Caspofungin concentrations

Pharmacology

Antimicrobial class: Echinocandin

Pregnancy category: C

Average serum half life: 10 hours

Biliary penetration: Therapeutic

Lung penetration: Therapeutic

Urine penetration: Poor

CSF penetration: Poor