Caspofungin

C. diff Risk

Low

Oral Bioavailability

NA

Approximate Cost

Dosing

70 mg IV once then 50 mg IV daily

The manufacturer provides to dosing guideline. Not studied.
Severe Impairment (Child-Pugh Class C):

70 mg IV once then 35 mg IV daily
Moderate Impairment (Child-Pugh Class B):

No adjustment required
Mild Impairment (Child-Pugh Class A):

General Information

Common Usage

Therapy of suspected and confirmed invasive fungal infections

Adverse Effects

  • ¬†Increased liver enzymes

  • ¬†GI upset

Major Interactions

Decreases levels of Tacrolimus
Cyclosporine may increase levels of Caspofungin
Rifampin may decrease Caspofungin concentrations

Pharmacology

Antimicrobial class: Echinocandin

Pregnancy category: C

Average serum half life: 10 hours

CSF penetration: Poor

Urine penetration: Poor

Biliary penetration: Therapeutic

Lung penetration: Therapeutic