LevoFLOXacin

C. diff Risk

High

Oral Bioavailability

Excellent

Approximate Cost

Non-formulary

Dosing

Adult

250-750mg PO/IV daily

General Information

Unacceptable Uses

Levofloxacin is non-formulary at MSH. Levofloxacin will be automatically substituted to Moxifloxacin for non-UTI indications or to Ciprofloxacin for UTI indications.

Common Usage

  • Lower respiratory infection (CAP, HAP)

  • Intraabdominal infection

Drug Monitoring

Monitor QTc in patients with increased risk

Adverse Effects

  • QTc prolongation

  • Dysglycemia

  • Rash

  • Tendinopathy and rupture

  • GI upset

  • Weakness exacerbation in myasthenia gravis

  • CNS toxicity including confusion, psychosis

Major Interactions

  • Other QTc prolonging agents

  • Divalent cations - Decreased absorption

  • NSAIDs - Increase seizure risk

  • Warfarin - Increased INR

Pharmacology

Antimicrobial class: Fluoroquinolone

Pregnancy category: C

Average serum half life: 7 hours

Biliary penetration: Therapeutic

Lung penetration: Therapeutic

Urine penetration: Therapeutic