C. diff Risk


Oral Bioavailability


Approximate Cost


100 mg PO BID

No adjustment required

General Information

Common Usage

  • Skin and soft tissue infection

  • Community acquired pneumonia

  • Malaria prophylaxis

  • Zoonoses

  • Methicillin resistant staphylococcus aureus infections

Adverse Effects

  • GI upset and erosive esophagitis

  • Photosensitivity rash

  • Teeth staining

Major Interactions

  • Divalent cations - decreased absorption

  • Increased digoxin levels

  • Increased INR with warfarin

  • Some anticonvulsants can decrease doxycycline levels

Additional Information

IV doxycline is only available through the Special Access Program


Antimicrobial class: Tetracycline

Pregnancy category: D

Average serum half life: 18 hours

Urine penetration: Therapeutic

Biliary penetration: Therapeutic

Lung penetration: Therapeutic

CSF penetration: Poor