Cystitis Macrobid 100 mg PO BID
Nitrofurantoin should be avoided
CrCl Less Than 30 mL/min
100 mg PO BID
CrCl Greater Than 30 mL/min
Uncomplicated cystitis in females with normal renal function
Interstitial pneumonitis and fibrosis especially with prolonged use.
Antacids decrease absorption
Think of this drug as a urinary antiseptic.
Not recommended in males due to inadequate tissue penetration, especially with possible occult prostatitis.
Antimicrobial class: Nitrofuran
Pregnancy category: B (Contraindicated at term)
Average serum half life: 1 hour
Biliary penetration: None
CSF penetration: None
Lung penetration: None
Urine penetration: Therapeutic