Nitrofurantoin

C. diff Risk

Low

Oral Bioavailability

Moderate

Approximate Cost

Dosing

Cystitis
Macrobid 100 mg PO BID

CrCl Less Than 30 mL/min
Nitrofurantoin should be avoided

CrCl Greater Than 30 mL/min
100 mg PO BID

General Information

Common Usage

Uncomplicated cystitis in females with normal renal function

Adverse Effects

Interstitial pneumonitis and fibrosis especially with prolonged use.

Peripheral neuropathy.

Major Interactions

Antacids decrease absorption

Additional Information

Think of this drug as a urinary antiseptic.

Not recommended in males due to inadequate tissue penetration, especially with possible occult prostatitis.

Pharmacology

Antimicrobial class: Nitrofuran

Pregnancy category: B (Contraindicated at term)

Average serum half life: 1 hour

Urine penetration: Therapeutic

CSF penetration: None

Biliary penetration: None

Lung penetration: None