Fosfomycin

C. diff Risk

Low

Oral Bioavailability

Moderate

Approximate Cost

Non-formulary

Dosing

Adult

Female, Uncomplicated UTI
3 g PO once

Renal

No adjustment required
No dosage adjustment necessary

General Information

Common Usage

Urinary Tract Infection, especially involving ESBL producing organisms

Offlabel - Prostatitis

Adverse Effects

  •  GI upset, especially diarrhea

  •  Headache

  •  Rhinitis, pharyngitis

Major Interactions

No significant interactions

Pharmacology

Antimicrobial class: Phosphonic acid derivative

Pregnancy category: B

Average serum half life: 6 hours

Urine penetration: Therapeutic