Respiratory Infection: 500mg PO/IV on day 1 then 250mg daily for 4 days Sinusitis: 500 mg po daily x 3 days Chlamydia, Chanchroid: refer to Canadian Guidelines to Sexually Transmitted Infections for full management: typically 1000 mg po as a single dose Consult specialist, Pharmacy or specific treatment guidelines for additional dosing regimens, including prophylaxis.
No adjustment required
Community acquired pneumonia
Upper respiratory tract infections
Mycobacterium avium complex (MAC) prophylaxis in HIV patients
Monitor QTc in patients with increased risk
Prolongation of QTc interval. Association with increased cardiovascular mortality in observational studies.
Prolonged half life may contribute to macrolide resistance
Other drugs that prolong QTc
Increases cyclosporine levels
May increase digoxin levels
Statins increased risk of rhabdomyolysis
Very high tissue penetration and concentration intracellularly means in vivo activity may not be predicted by in vitro testing - e.g. Salmonella species.
Antimicrobial class: Macrolide
Pregnancy category: B
Average serum half life: 68 hours
Biliary penetration: Therapeutic
CSF penetration: Poor
Lung penetration: Therapeutic
Urine penetration: Poor