Meropenem

C. diff Risk

Medium

Oral Bioavailability

NA

Approximate Cost

Dosing

Adult

Standard Dose
500mg IV q6h or 1g IV q8h

Meningitis
2g IV q8h

General Information

Common Usage

Therapy of serious, often nosocomial infections involving resistant gram negative organisms

Adverse Effects

  •  Immediate and delayed-type allergy

  •  GI disturbance

  •  Cytopenias, positive Coombs

  •  Liver enzyme abnormalities

Major Interactions

Valproic acid - Carbapenems decrease valproate levels and may decrease seizure threshold

Pharmacology

Antimicrobial class: Carbapenem

Pregnancy category: B

Average serum half life: 1 hour

Biliary penetration: Therapeutic

CSF penetration: Moderate

Lung penetration: Therapeutic

Urine penetration: Therapeutic