Non-formulary at MSH.
Candida infections both mucocutaneous and invasive - i.e. Candidemia.
Antifungal prophylaxis in immunocompromised patients.
Rationale for monitoring voriconazole levels:
Accepted therapeutic trough range: 1-5 mg/L
How to order levels:
Other suggested monitoring:
CYP450 interactions ++.
Other QTc prolonging agents.
Recommend review of pt medications due to high frequency of significant interactions.
Antimicrobial class: Triazole antifungal, Second generation
Pregnancy category: D
Average serum half life: Variable, dose-dependent. Steady-state is achieved by day 3 when an IV loading dose is administered and between days 5 and 8 if no loading dose is used (Purkins 2003).
CSF penetration: Therapeutic
Lung penetration: Therapeutic
Urine penetration: Poor