Invasive Aspergillosis
IV:
Oral:
Loading dose:
Maintenance dose:
Candidemia and Invasive Candidiasis
IV:
Loading dose: 6 mg/kg IV q12h x 2 doses
Maintenance dose: 3-4 mg/kg IV q12h
Oral:
Loading dose:
Maintenance dose:
Notes
Therapy should be initiated with specific loading dose regimen depending on the indication for use. Loading regimen is for the first 24 hours of therapy.
Loading dose and maintenance dose reduction may be required for low body weight less than 40 kg and specific indication for use.
Dose adjustment may be required if patient response is inadequate or patient is unable to tolerate treatment.
When voriconazole is taken concomitantly with interacting drugs (i.e. in patients receiving concomitant CYP450 enzyme inducers or substrates), dose adjustment of voriconazole or the concomitant drug may be required. Review patient specific drug interaction concerns with pharmacy.