Amoxicillin-Clavulanate

C. diff Risk

Medium

Oral Bioavailability

Excellent

Approximate Cost

Dosing

Adult

875mg PO BID or 500mg PO TID of the amoxicillin component

Renal

CrCl Greater Than 50 mL/min
500-875 mg BID

CrCl 25-49 mL/min
500-875 mg BID

CrCl 10-24 mL/min
250-500 mg BID

CrCl Less Than 10 mL/min
250-500 mg q24h

General Information

Common Usage

Prophylaxis/treatment of bite wounds.

Polymicrobial infections of the respiratory tract or abdomen.

Skin and soft tissue infections.

Drug Monitoring

For prolonged therapy, monitor liver enzymes and function.

Adverse Effects

  •  Allergy/rash (immediate or delayed)

  •  Note EBV related rash

  •  Cytopenias

  •  Diarrhea

  •  Hepatotoxicity due to clavulanate - usually mild, liver failure is rare.

Major Interactions

Increased risk of rash with allopurinol

Pharmacology

Antimicrobial class: Aminopenicillin + Beta-lactamase inhibitor

Pregnancy category: B

Average serum half life: 1 hour

Urine penetration: Therapeutic

Lung penetration: Therapeutic

Biliary penetration: Therapeutic