Amoxicillin

C. diff Risk

Low

Oral Bioavailability

Excellent

Approximate Cost

Spectrum Of Activity

Dosing

CrCl Less Than 10 mL/min250-500 mg q24h

CrCl 10-30 mL/min250-500 mg BID

CrCl Greater Than 30 mL/min250-500 mg TID

250-500 mg po TID. Some guidelines may recommend higher dosing.

General Information

Common Usage

Therapy of Streptococcal and Enterococcal infections as well as susceptible gram negative infections.

Commonly used for upper respiratory infections and urinary tract infections.

Adverse Effects

  •  Allergy/rash (immediate or delayed)

  •  Note EBV related rash

  •  Cytopenias

Major Interactions

Allopurinol - increased rash

Pharmacology

Antimicrobial class: Aminopenicillin

Pregnancy category: B

Average serum half life: 1 hour

Biliary penetration: Therapeutic

CSF penetration: Moderate with inflamed meninges only

Lung penetration: Therapeutic

Urine penetration: Therapeutic