Ampicillin

C. diff Risk

Low

Oral Bioavailability

NA

Approximate Cost

Dosing

Adult

1-2g IV q4-6h

2g IV q4h for meningitis or endocarditis

General Information

Common Usage

Pathogen directed therapy for CNS, intravascular, intraabdominal, urinary and other infections especially Enterococcus and Listeria

Adverse Effects

Allergy and rash as for all beta-lactams.

EBV related rash (not allergy).

Rare: cytopenias, +ve Coombs.

Major Interactions

Increased risk of rash with allopurinol.

Pharmacology

Antimicrobial class: Aminopenicillin

Pregnancy category: B

Average serum half life: 1 hour

Biliary penetration: Therapeutic

CSF penetration: Therapeutic with inflamed meninges

Lung penetration: Therapeutic

Urine penetration: Therapeutic