C. diff Risk


Oral Bioavailability


Approximate Cost


1-2g IV q4-6h 2g IV q4h for meningitis or endocarditis

1-2 g q12-24 h
CrCl Less Than 10 mL/min

1-2 g q6-12h
CrCl 25-49 mL/min

1-2 g q4-6h
CrCl Greater Than 50 mL/min

1-2 g q6-12h
CrCl 10-24 mL/min

General Information

Common Usage

Pathogen directed therapy for CNS, intravascular, intraabdominal, urinary and other infections especially Enterococcus and Listeria

Adverse Effects

Allergy and rash as for all beta-lactams.

EBV related rash (not allergy).

Rare: cytopenias, +ve Coombs.

Major Interactions

Increased risk of rash with allopurinol.


Antimicrobial class: Aminopenicillin

Pregnancy category: B

Average serum half life: 1 hour

Biliary penetration: Therapeutic

CSF penetration: Therapeutic with inflamed meninges

Lung penetration: Therapeutic

Urine penetration: Therapeutic