C. diff Risk


Oral Bioavailability


Approximate Cost


CrCl Less Than 10 mL/min1-2 g q12-24 h

CrCl 25-49 mL/min1-2 g q6-12h

CrCl Greater Than 50 mL/min1-2 g q4-6h

CrCl 10-24 mL/min1-2 g q6-12h

1-2g IV q4-6h

2g IV q4h for meningitis or endocarditis

General Information

Common Usage

Pathogen directed therapy for CNS, intravascular, intraabdominal, urinary and other infections especially Enterococcus and Listeria.

Adverse Effects

Allergy and rash as for all beta-lactams.

EBV related rash (not allergy).

Rare: cytopenias, +ve Coombs.

Major Interactions

Increased risk of rash with allopurinol.


Antimicrobial class: Aminopenicillin

Pregnancy category: B

Average serum half life: 1 hour

Biliary penetration: Therapeutic

CSF penetration: Therapeutic with inflamed meninges

Lung penetration: Therapeutic

Urine penetration: Therapeutic