1-2 gm IV q8h
CrCl Less Than 10 mL/min
1-2 g q24h
CrCl Greater Than 50 mL/min
1-2 g q8h
Skin bone and soft tissue infection (e.g. cellulitis, osteomyelitis).
Susceptible Staphylococcal, Streptococcal and gram negative infections.
Cardiovascular infections including endocarditis
Some intra-abdominal infections
Allergy (immediate or delayed).
Can cause positive Coombs, cytopenias, and hepatic and renal laboratory abnormalities.
CNS: seizure risk increases
GI disturbances (nausea, diarrhea)
Probenecid - prolonged half-life. Drug interaction has been used therapeutically to give once daily cefazolin.
May increase levels/effects of: Fosphenytoin; Phenytoin; Vitamin K antagonists (including warfarin)
May decrease levels/effects of: BCG vaccine, Cholera vaccine, Typhoid vaccine; Sodium Picosulfate; Estriol; Lactobacillus.
Antimicrobial class: 1st Generation Cephalosporin
Pregnancy category: B
Average serum half life: 2 hours
Urine penetration: Therapeutic
CSF penetration: Poor
Biliary penetration: Therapeutic
Lung penetration: Therapeutic