C. diff Risk


Oral Bioavailability


Approximate Cost


1-2 gm IV q8h

CrCl Less Than 10 mL/min1-2 g q24h

CrCl 10-24 mL/min1-2 g q12h

CrCl 25-49 mL/min1-2 g q12h

CrCl Greater Than 50 mL/min1-2 g q8h

General Information

Common Usage

Skin bone and soft tissue infection (e.g. cellulitis, osteomyelitis).

Surgical prophylaxis.

Susceptible Staphylococcal, Streptococcal and gram negative infections.

Cardiovascular infections including endocarditis

Some intra-abdominal infections


Adverse Effects

Allergy (immediate or delayed).

Can cause positive Coombs, cytopenias, and hepatic and renal laboratory abnormalities.

CNS: seizure risk increases

GI disturbances (nausea, diarrhea)

Major Interactions

Probenecid - prolonged half-life. Drug interaction has been used therapeutically to give once daily cefazolin.

May increase levels/effects of: Fosphenytoin; Phenytoin; Vitamin K antagonists (including warfarin)

May decrease levels/effects of: BCG vaccine, Cholera vaccine, Typhoid vaccine; Sodium Picosulfate; Estriol; Lactobacillus.


Antimicrobial class: 1st Generation Cephalosporin

Pregnancy category: B

Average serum half life: 2 hours

Biliary penetration: Therapeutic

CSF penetration: Poor

Lung penetration: Therapeutic

Urine penetration: Therapeutic