ValACYclovir
Renal

Renal

In the setting of rapidly improving or worsening renal function, calculations of CrCl are inaccurate. Dosing should be based on estimated renal function instead.

If improving renal function, actual CrCl is likely higher than calculated CrCl.

If worsening renal function, actual CrCl is likely lower than calculated CrCl.

Herpes zoster

CrCl Greater Than 50 mL/min

1000 mg q8h

CrCl 30-49 mL/min

1000 mg q12h

CrCl 10-29 mL/min

1000 mg q24h

CrCl Less Than < 10 mL/min

500mg q24h

Genital herpes (Initial)

CrCl Greater Than 50 mL/min

1000 mg q12h

CrCl 30-49 mL/min

1000 mg q12h

CrCl 10-29

1000 mg q24h

CrCl Less Than 10 mL/min

500 mg q24h

Genital herpes (Recurrent)

CrCl Greater Than 50 mL/min

500 mg q12h

CrCl 30-49 mL/min

500 mg q12h

CrCl 10-29 mL/min

500 mg q24h

CrCl Less Than 10 mL/min

500 mg q24h

Herpes Labialis (Cold Sores)

CrCl Greater Than 50 mL/min

2000 mg q12h x 2 doses

CrCl 30-49 mL/min

1000 mg q12h x 2 doses

CrCl 10-29 mL/min

500 mg q12h x 2 doses

CrCl Less Than 10 mL/min

500 mg single dose