Clostridium difficile


Contact Precautions
Contact Precautions

General Information

Pathogen information

Anaerobic spore forming gram positive bacilli, box-car shaped


Nosocomial more common than community onset diarrhea usually after taking antibiotics.

Can occur in outbreaks.

Recurrence is very common therefore previous history of C. difficile is a risk factor.

Antacids, especially proton-pump inhibitors, and chemotherapy also increase risk.

Associated syndromes

Wide range of symptoms possible.

  • Profuse, watery diarrhea

  • Pseudomembranous colitis or toxic megacolon.

Additional Information

In refractory cases, stool transplants have been effective.