Fever is defined as a single oral temperature of 38.3°C or greater or a temperature of 38°C or greater for 1 hour or more.
Neutropenia is defined as an absolute neutrophil count (ANC) of 0.5 x 10⁹/L or less, or an ANC of 1 x 10⁹/L or less, with a predicted decrease to 0.5 x 10⁹/L or less within 48 hours.
Febrile neutropenia is considered an oncologic emergency and timely assessment and initiation of empiric therapy is indicated.
Neutropenia With Fever
(MASCC Scoring System)
Neutropenia Without Fever
Tests and Cultures
Usual Causative Organisms
Initiation of Empiric Therapy
IV Combination Therapy versus Monotherapy
Empiric Antimicrobial Regimens
Duration of Therapy
Reevaluation of Therapy
Use of G-CSF
(Granulocyte Colony-Stimulating Factor)
Antimicrobial Stewardship Committee
Drugs and Therapeutics Committee
Original Approval Date