GBS Prophylaxis

Treatment Notes

Treat all women with intrapartum fever and signs of chorioamnionitis with broad spectrum intravenous antibiotics targeting chorioamnionitis and including coverage for GBS, regardless of GBS status and gestational age.

Recommended Regimens

An adequate duration of IAP is defined as antibiotic given greater than or equal to 4 hours before delivery

1 - MMWR November 19, 2010 / 59(RR-10); Prevention of Perinatal Group B Streptococcal Disease Revised.

2 - Onwuchuruba CN, Towers CV, Howard BC, et al. Transplacental passage of vancomycin from mother to neonate. Am J of Obste Gynecol. 2014; 210(4): 352-352.

3 - MSH Maternal Child System Manual. Group B Streptococcal (GBS) Disease: Maternal and Neonatal Management; 550.601.165.

4 - Society of Obstetricians and Gynaecologists of Canada. The Prevention of Early-Onset Neonatal Group B Streptococcal Disease. J. Obstet Gynaecol Can 2013; 35(10): 939-948.