Acyclovir - Renal - Adult Dosing

Use ideal body weight for dosing

CrCl > 50 mL/min

5 mg/kg/dose IV Q8h

CrCl 10 - 50 mL/min

5 mg/kg/dose IV Q12 -24h

CrCl < 10mL/min (ESRD not on HD)

2.5 mg/kg IV Q24h

Dialysis (HD)

2.5mg/kg IV x1 now then 2.5 mg/kg QPM (give PHD on HD days)

Dialysis (CRRT)

5mg/kg Q24h

CrCl > 50 mL/min

10 mg/kg/dose IV Q8h

CrCl 10 - 50 mL/min

10 mg/kg/dose IV Q12 - 24h

CrCl < 10mL/min (ESRD not on HD)

5 mg/kg IV Q24h

Dialysis (HD)

5mg/kg IV x1 now then 5 mg/kg QPM (give PHD on HD days)

Dialysis (CRRT)

5-10mg/kg Q12h -24h