Amikacin - Pediatric Dosing

Creatinine Clearance >50mL/min/1.73m²

Uncomplicated Infection
15mg/kg/dose Q24H

Cystic Fibrosis
30mg/kg/dose Q24H

Check amikacin level 8 hours (6-14 hours) after start of 30 minute infusion of first dose.

Dosing interval (q24H, q36H, q48H) dependent upon Extended Interval Level and reference to the Extended Interval Dosing Nomogram.

Creatinine Clearance 10-50mL/min/1.73m²

Dosing interval (Q36H or Q48H) dependent upon Extended Interval Level and reference to the Extended Interval Dosing Nomogram

Creatinine Clearance ≤10mL/min/1.73m²

Do not use extended interval dosing.
Discuss with Pharmacy.

Note

Obtain Trough within 30 min before the next dose and Peak 30 min after 30 min infusion.

Goal Peak: 25-35 mcg/mL.
Goal Trough: <5 mcg/mL

Creatinine Clearance >50mL/min/1.73m²

Uncomplicated Infection
7.5mg/kg/dose Q8H

Cystic Fibrosis
10mg/kg/dose Q8H

Creatinine Clearance 10-50mL/min/1.73m²

5-7.5mg/kg/dose Q 12-24H

Creatinine Clearance ≤10mL/min/1.73m²

2.5-5mg/kg/dose x 1
Monitor 24 hour level
Target level <5 mcg/mL