Amoxicillin-Clavulanate

C. diff Risk

Medium

Oral Bioavailability

Excellent

Approximate Cost

$

Dosing

Adult

875mg PO BID or 500mg PO TID of the amoxicillin component

Renal

Dose reduction for CrCl < 30

General Information

Common Usage

Prophylaxis/treatment of bite wounds

Polymicrobial infections of the respiratory tract or abdomen

Skin and soft tissue infections

Drug Monitoring

For prolonged therapy monitor liver enzymes and function

Adverse Effects

Hepatotoxicity due to clavulinate- usually mild, liver failure is rare

Allergy/rash (immediate or delayed), cytopenias, diarrhea. Note EBV related rash

Major Interactions

Increased risk of rash with allopurinol

Pharmacology

Antimicrobial class: Aminopenicillin + Beta-Lactamase inhibitor

Pregnancy category: B

Average serum half life: 1 hour

Biliary penetration: Therapeutic

Lung penetration: Therapeutic

Urine penetration: Therapeutic