Ampicillin

C. diff Risk

Low

Oral Bioavailability

Moderate

Approximate Cost

$$

Dosing

Adult

1-2g IV q4-6h

2g IV q4h for meningitis or endocarditis

General Information

Common Usage

Pathogen directed therapy for CNS, intravascular, intraabdominal, urinary and other infections especially Enterococcus and Listeria

Drug Monitoring

CBC CMP once weekly

Adverse Effects

Allergy and rash as for all beta-lactams

EBV related rash (not allergy)

Rare: cytopenias, +ve Coombs

Major Interactions

Increased risk of rash with allopurinol

Pharmacology

Antimicrobial class: Aminopenicillin

Pregnancy category: B

Average serum half life: 1 hour

Biliary penetration: Therapeutic

CSF penetration: Therapeutic

Lung penetration: Therapeutic

Urine penetration: Therapeutic