Aztreonam

Restricted
Restricted

C. diff Risk

Medium

Oral Bioavailability

NA

Approximate Cost

$$$$

Dosing

Adult

2g IV q8h for severe infections

Restricted Use

Aerobic gram-negative infections in beta-lactam allergic patients.

General Information

Common Usage

Therapy of gram negative infections including Pseudomonas, particularly in patients with penicillin and cephalosporin allergy or when there is no alternative susceptible agent

Nebulized form used in cystic fibrosis patients (Cayston)

Empiric therapy for febrile neutropenia with severe penicillin allergy when combined with additional Gram positive agent

Drug Monitoring

Laboratory

  • Cr weekly (for dose-adjustment assessment)

Clinical

  • Hypersensitivity

  • Diarrhea

Adverse Effects

  • GI effects

  • Hypersensitivity

Additional Information

Has no Gram positive or anaerobic coverage

Pharmacology

Antimicrobial class: Monobactam

Pregnancy category: B

Average serum half life: 2 hours

Biliary penetration: Moderate

Lung penetration: Therapeutic

Urine penetration: Therapeutic