Cefazolin

C. diff Risk

Medium

Oral Bioavailability

NA

Approximate Cost

$

Dosing

Adult

1-2 g IV q8h (max 6 gm/day)

General Information

Common Usage

Skin and soft tissue infection (i.e. cellulitis).

Surgical prophylaxis.

Susceptible Staphylococcal, Streptococcal and Gram negative infections.

Drug Monitoring

Laboratory

  • CBC, CMP weekly

Clinical

  • Hypersensitivity

  • Diarrhea

  • Other GI effects

Adverse Effects

  • GI effects

  • Hypersensitivity reactions

  • C. difficile

Major Interactions

Probenecid - prolonged half-life. Drug interaction has been used therapeutically to give once daily cefazolin

Not recommended unless no other alternatives

Pharmacology

Antimicrobial class: 1st Generation Cephalosporin

Pregnancy category: B

Average serum half life: 2 hours

Biliary penetration: Therapeutic

CSF penetration: Poor

Lung penetration: Therapeutic

Urine penetration: Therapeutic